Endocrine Abstracts

Introduction: For defining SH in AI patients at least 2 altered criteria among serum cortisol after 1 mg dexamethasone test (1 mgDST), ACTH levels, 24 h urinary free cortisol (UFC) and midnight serum cortisol levels are generally required. Midnight salivary cortisol (MSC), a sensitive and easy-to-perform marker of overt hypercortisolism, appears to be of limited utility in these patients. Data on the role of salivary cortisol using LC-MS/MS, the gold standard procedure for ste...

Introduction: Subclinical hypercortisolism (SH), affecting about 30% of patients with unilateral adrenal incidentaloma (UAI), has been associated to hypertension (HT), type 2 diabetes mellitus (T2DM), dyslipidemia (DL), osteoporosis and vertebral fractures (FX). The prevalence of SH in patients with bilateral adrenal incidentaloma (BAI) seems to be even higher. Data on metabolic and bone complications in these patients are lacking.Methods/design: We enro...

Introduction: Patients with adrenal incidentalomas (AI) and subclinical hypercortisolism (SH) are thought to have increased incidence of cardiovascular risk factors, including diabetes mellitus (DM) and hypertension. Data regarding dyslipidemia are scarce. The aim of this study is to evaluate the possible influence of SH on lipid pattern in relation to the presence/absence of DM.Methods and design: 276 AI patients were enrolled (168 F, 108 M), 55 with di...

Background and objectives: There are a lot of studies demonstrating low bone mineral density (BMD) and elevated fracture risk in patients with type 1 diabetes. But there are scarce data about the prevalence of morphometric vertebral fractures (MorfoFx) and spinal deformity index (SDI) that is considered as a surrogate marker of bone quality. Therefore, the objective of this study was to evaluate BMD, the prevalence of MorfoFx and bone quality by SDI in type 1 diabetics.<p ...

Aim: To investigate factors associated with low bone mineral density (BMD) in type-1 diabetic (T1D) patients.Patients and methods: One hundred and seventy-five eugonadal T1D patients (age 32.8±8.4 years, diabetes duration 13.0±8.4 years) were studied. Body mass index (BMI), daily insulin dose (DID), age at diagnosis (AgeD), presence of diabetic complications, glomerular filtration rate (GFR), HbA1c, and BMD at lumbar spine (LS) and femur (F) by...

Previous studies suggest that in patients with adrenal incidentalomas (AI) subclinical hypercortisolism (SH) exerts a deleterious effect on bone mineral density (BMD), but scarce data are available about vertebral fractures. We evaluate BMD and prevalence of vertebral fractures in a sample of AI subjects with and without SH.Forty-seven consecutive AI inpatients were evaluated (17M, 30F). The patients were subdivided into two groups: with or without subcl...

In order to evaluate hypothalamic-pituitary-adrenal activity in diabetic patients in relation to neuroautonomic balance, we studied 50 consecutive hospitalized T2D patients (22F, 28M) without symptoms of neuropathy or hypercortisolism. We measured: morning, midnight and post-dexamethasone suppression cortisol (F8, F24 and F-Dex respectively) 24-hours urinary free cortisol (UFC), morning ACTH, systolic and diastolic blood pressure levels (SBP, DBP) and performed deep-breathing ...

Background: Vitamin D deficiency plays a role in autoimmune diseases and risk of fractures. No data are available on vitamin D levels and vertebral fractures in autoimmune bullous skin diseases.Objectives: To assess vitamin D serum levels and vertebral fractures’ prevalence in patients with pemphigus vulgaris (PV) and bullous pemphigoid (BP), potentially deadly autoimmune bullous disorders.Methods: We studied 13 consecutive ac...